Objective: To investigate the correlation between ibuprofen suspension and severe erythema multiforme

so as to provide reference for the safe use of ibuprofen. Methods: One case of severe erythema multiforme induced by ibuprofen suspension was analyzed and the literature was reviewed. Results: According to adverse drug reaction / event correlation evaluation criteria from National Center for Adverse Drug Reaction Monitoring

severe erythema multiforme induced by ibuprofen suspension had higher probability. After literature review

most skin adverse drug reactions induced by ibuprofen were mild drug eruptions

and severe drug eruptions were rare. There were also individual reports of severe skin adverse drug reactions induced by ibuprofen

such as erythema multiforme

StevensJohnson syndrome

toxic epidermolysis bullosa

exfoliative dermatitis

and hypersensitivity syndrom. Conclusion: Ibuprofen is widely used clinically and well tolerated

yet caution is needed for its severe skin adverse drug reactions.